艾启迪
职称/职位
讲师
社会兼职
中国药理学会补益药药理专业委员会委员
中国民族医药学会药理毒理分会理事
世界中医药学会联合会网络药理学专业委员会理事
课程教学
《细胞工程》，《中药生物技术》，《药理学》
研究方向
研究领域：中药心脑血管药理
研究兴趣：
1.脑卒中及其并发症相关中药药效物质基础及作用机制研究
2.冠心病相关中药药效物质基础及作用机制研究
科研项目
1.湖南省教育厅优秀青年项目（21B0354，2022/01-2024/12，主持）
2.长沙市自然科学基金（kq2202269，2022/01-2024/12，主持）
3.pp电子中国官网平台校级基金重点项目（2019xjjj001，2020/07-2023/07，主持）
4.横向课题（212010，2021/01-2022/12，主持）
5.教育部重点实验室开放基金项目（P201802，2019/01-2020/12，主持）
6.国家自然科学基金面上项目（82174271，2022/01-2025/12，参与）
7.国家自然科学基金地区科学基金项目（81560665，2016/01-2019/12，参与）
8.国家自然科学基金面上项目（81374011，2014/01-2017/12，参与）
代表论文
1.Ai, Q.;Chen, C.; Chu, S.; Luo, Y.; Zhang, Z.; Zhang, S.; Yang, P.; Gao, Y.; Zhang, X.; Chen, N*. IMM-H004 Protects against Cerebral Ischemia Injury and Cardiopulmonary Complications via CKLF1 Mediated Inflammation Pathway in Adult and Aged Rats. Int. J. Mol. Sci. 2019, 20, 1661
2.Qidi Ai,Chen Chen, Shifeng Chu, Zhao Zhang, Yun Luo, Fei-fei Guan, Shuai Zhang, Shasha Wang, Xu Yan, Naihong Chen*, IMM-H004 Therapy for Permanent Focal Ischemic Cerebral Injury via CKLF1/CCR4-mediated NLRP3 Inflammasome Activation. Translational research, 2019, 212: 36-53
3.Qidi Ai;Guibo Sun*; Yun Luo; Xi Dong; Ruifeng Hu; Xiangbao Meng; Xiaobo Sun*; Ginsenoside Rb1 prevents hypoxia-reoxygenation-induced apoptosis in H9c2 cardiomyocytes via an estrogen recep tor-dependent crosstalk among the Akt, JNK, and ERK 1/2 pathways using a label-free quantitative proteomics analysis, RSC Advances, 2015, 5(33): 26346-26363
4.Sun Yang; Liu Shasha; Yang Songwei; Chen Chen; Yang Yantao; Lin Meiyu; Liu Chao; Wang Wen mao; Zhou Xudong;Ai Qidi*;Wang Wei*; Chen Naihong*; Mechanism of Dihydromyricetin on Inflammatory Diseases, Frontiers in Pharmacology, 2022, 12
5.Chen C*,Ai Q,Shi A, Wang N, Wang L, Wei Y*, Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders. Nutr Neurosci. 2022 Mar 21:1-15
6.Chen Chen,Qi-Di Ai,Shi-Feng Chu, Zhao Zhang, Nai-Hong Chen*, NK cells in cerebral ischemia. Biomedicine & Pharmacotherapy, 2018.10.20, 109(2019): 547–554
7.Chen Chen,Qidi Ai,Shifeng Chu, Zhao Zhang, Xin Zhou, Piao Luo, Yingjiao Liu, Naihong Chen*, IMM-H004 protects against oxygen-glucose deprivation/reperfusion injury to BV2 microglia partly by modulating CKLF1 involved in microglia polarization, International Immunopharmacology, 2019.02.06, 70(2019): 69–79
8.Chen C*,Ai Q-d,Wei Y-h*, Potential role of hydroxytyrosol in neuroprotection. Journal of Functional Foods, 2021; 82: 104506
9.Chen C*,Ai Q,Wei Y*, Hydroxytyrosol protects against cisplatin- induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. Int Immunopharmacol. 2021 Jul; 96: 107805
10.Chen C*,Ai QD,Wei YH*. Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux. J Ethnopharmacol. 2021 Jan 10; 264: 113388
11.Yang S, Chu S,Ai Q,Zhang Z, Gao Y, Lin M , Liu Y, H u Y, Li X, Peng Y, Pan Y, He Q, Chen N*,Anti-inflammatory effects of higenamine (Hig) on LPS-activated mouse microglia (BV2) through NF-κB and Nrf2/HO-1 signaling pathways. Int Immunopharmacol. 2020 Aug; 85: 106629
12.Chen Chen, ShiFeng Chu,QiDi Ai,Zhao Zhang, FeiFei Guan, ShaSha Wang, YiXiao Dong, Jie Zhu, WenXuan Jian, NaiHong Chen*, CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4. Cellular and Molecular Neurobiology, 2019, 39(5): 651~669
13.Zhao Zhang, ShiFeng Chu, ShaSha Wang, YiNa Jiang, Yan Gao, PengFei Yang,QiDi Ai,NaiHong Chen*, RTP801 is a critical factor in the neurodegeneration process of A53T α‐synuclein in a mouse model of Parkinson's disease under chronic restraint stress, British Journal of Pharmacology, 2017, 175(4)
14.Yun Luo, Shan Lu,Qidi Ai,Ping Zhou, Meng Qin, Guibo Sun*, Xiaobo Sun*, SIRT1/AMPK and Akt/eNOS signaling pathways are involved in endothelial protection of total aralosides of Aralia elata (Miq) Seem against high‐fat diet‐induced atherosclerosis in ApoE−/− mice, Phytotherapy Research. 2019;1–11
15.Songwei Yang, Shifeng Chu, Yan Gao,Qidi Ai,Yingjiao Liu, Xun Li and Naihong Chen*, A Narrative Review of Cancer-Related Fatigue (CRF) and Its Possible Pathogenesis, Cells 2019, 8, 738
16.Yang S#, Yang Y#, Chen C, Wang H,Ai Q,Lin M, Zeng Q, Zhang Y, Gao Y, Li X, Chen N*, The Anti-Neuroinflam matory Effect of Fuzi and Ganjiang Extraction on LPS-Induced BV2 Microglia and Its Intervention Function on Depression-Like Behavior of Cancer-Related Fatigue Model Mice. Front Pharmacol. 2021 May 28; 12: 670586
联系方式
电话：13357329630
邮箱：278339420@qq.com
