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彭求贤

2017/06/22 22:26:31人浏览

彭求贤,男,1983年11月生,湖南衡阳人,中药学博士,中西医结合博士后。副研究员。主要从事中药抗肿瘤作用物质基础和机制研究,中药抗神经退行性疾病研究。主持中国博士后项目2项,广东省科技厅项目1项,博士启动基金1项。发表论文40余篇,其中SCI论文10余篇。讲授《中药药理学》、《药理学》、《临床药理学》、《药理学实验》和《机能学实验》等课程。

一、代表论文

1. Peng Q*, Cai H, Sun X, Li X, Mo Z, Jue S. Alocasia cucullata Exhibits Strong Antitumor Effect in Vivo by Activating Antitumor Immunity. PLoS ONE 2013; 8(9): e75328. doi:10.1371/journal.pone. 0075328

2. Peng Qiu-xian*, Cai Hong-bin*, Peng Jiang-li*, Shi Jue, Mo Zhi-xian.Extract of a potent Chinese medicine, Zuojin, induces apoptosis of SGC-7901 cells via mitochondria dependent pathway. Chinese Journal of Integrative Medicine, 2015 Apr 6.

3. J.L.PENG*,Q.X. PENG*,L.M. LIN, W.W.DONG, T.S. LIU, D.J. YANG. Simultaneous Determination of 13 Nucleosides and Nucleobases in Ganoderma lucidum and Related Species by HPLC-DAD. Asian Journal of Chemistry 2014; 26(12): 3477-3482.(共同第一作者)

4. Wei Liu*,Qiu-Xian Peng*, Xiao-Liang Lin, Chao-Hua Luo, Ming-Jin Jiang, Zhi-Xian Mo, Ken Kin-Lam Yung. Effect of Rhynchophylline on the expression of p-CREB and c-Fos in striatum and hippocampal CA1 area of methamphetamine-induced conditioned place preference rats. Fitoterapia 2014; 92: 16–22. (Co-first author) (Co-first author)

5. Qiuxian Peng*, Qin Zhang*, Wei Xiao, Meng Shao, Qin Fan, Hongwei Zhang, Yukai Zou, Xin Li, Wenxue Xu, Zhixian Mo, Hongbing Cai. Protective effects of Sapindus mukorossi Gaertn against fatty liver disease induced by high fat diet in rats.Biochemical and Biophysical Research Communications 2014;450 (1): 685-691.

6. Yao Liu*, Wei Liu*,Qiuxian Peng, Jiangli Peng, Linzhong Yu, Jianlan Hu. Protective effect of Huoxiang Zhengqi oral liquid on intestinal mucosal mechanical barrier of rats withpost-infectious irritable bowel syndromeinduced by acetic acid. Evidence-Based Complementary and Alternative Medicine 2014. 218383-218383.

7. Junkui Li*, Wei Liu*,Qiuxian Peng*,Mingjin Jiang, Chaohua Luo, Youli Guo, Yi Liu, Miao Fang, Zhixian Mo. Effect of rhynchophylline on coitioned place preference on expression of NR2B in methamphetamine-dependent mice. Biochemical and Biophysical Research Communications,2014,452(3):695-700. (Co-first author)

8. Mingjin Jiang*,Jin Li*,Qiuxian Peng*, Ju Peng, Wei Liu, Chaohua Luo, Junkui Li and Zhixian Mo. Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injuryare associated with down-regulate the expression of p-JNK1/2 and p-p38 MAPK. BMC Journal of Neuroinflammation. 2014,(Co-first author).

9. Cai LM,Lyu XM,Luo WR,Cui XF,Ye YF,Yuan CC,Peng QX,Wu DH,Liu TF,Wang E,Marincola FM,Yao KT,Fang WY,Cai HB,Li X. EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN. Oncogene. 2014 Oct 27. doi: 10.1038/onc.2014.341.

10. Mingjin Jiang, Yifei Chen, Chan Li,Qiuxian Peng, Miao Fang, Wei Liu,Qunzhao Kang, Yingbo Lin, Ken Kin Lam Yung, Zhixian Mo, Inhibiting effects of rhynchophylline on zebrafish methamphetamine dependence are associated withamelioration of neurotransmitters content and down-regulation of TH and NR2B expression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 68,4 July 2016, Pages 31–43

11. Peng Qiuxian, Cai Hongbin, Peng Jiangli, Wen Jianlin,Yung Kin Lam, Mo Zhixian, Extract of Zuojin Pill Induces Apoptosis of SGC-7901 Cells via Mitochondria-Dependent Pathway, Chinese Journal of Integrative Medicine, 2015.11:39-47.

12. 彭求贤,杨大坚,史珏,蔡红兵,莫志贤.黄连、吴茱萸诱导人胃癌细胞SGC-7901凋亡的配比研究[J].南方医科大学学报, 2011;31(2):225-229

13. 彭求贤,蔡红兵,史珏,彭江丽,莫志贤.黄连配伍吴茱萸后生物碱类成分的含量变化[J].中药材, 2012; 5 :742-745.

14. 彭求贤,余惠旻,胡胜全,刘塔斯,杨大坚,陈新滋.左金丸诱导人胃癌细胞SGC-7901凋亡的研究[J].江苏中医药,2009,41(4):70-71.

15. 彭求贤,余惠旻,刘塔斯,张慧青,杨大坚,陈新滋.左金丸与反左金丸诱导人胃癌细胞SGC-7901凋亡的比较研究[J].肿瘤防治研究,2009,36(6):459-461.

16. 汤伟,彭求贤,严愉妙,莫志贤,黄少慧,李欣,蔡红兵.大孔吸附树脂法及离子交换层析柱法精制纯化丹参多糖的研究[J].中药材, 2010,33(12):1937-1941.

17. 汤伟,彭求贤,蔡红兵,李欣,莫志贤.丹参多糖对免疫抑制小鼠单核吞噬细胞吞噬功能的影响[J].时珍国医国药,2011,22(10):2484-2485.

18. 余惠旻,彭求贤,刘塔斯,杨大坚,陈新滋.反左金丸对人胃癌细胞SGC-7901凋亡及bcl-2、bax基因表达的影响[J].中国实验方剂学杂志,2008,14(11):28-31.

19. 张勤,彭求贤,蔡红兵,莫志贤.无患子的研究进展[J].医药导报, 2012,31(9):1171-1173.

20. 张勤,蔡红兵,莫志贤,史珏,孙学刚,彭求贤,杨明会.鸡骨草防治大鼠脂肪肝的实验研究[J].中药材, 2012;35(9):1450-1455.

21. 周红祖,余惠旻,彭求贤,杨大坚,陈新滋.黄连与吴茱萸及其不同配伍的化学成分、药理及药性研究进展[J].中国实验方剂学杂志,2008,14(9):75-77.

22. 彭求贤,彭江丽,刘塔斯,罗堃,莫志贤.含羞草水提物对人子宫癌Hela细胞凋亡及mcl-1与bim蛋白表达基因表达的影响[J].时珍国医国药,2015, 26(1):78-79.

23. 彭求贤,彭江丽,江明金,刘伟,张世卿,李俊葵,蔡红兵,莫志贤.丹参多糖对痤疮丙酸杆菌和脂多糖诱导小鼠肝炎的保护作用[J].时珍国医国药,2015.26(7):1605-1607

24. 彭求贤,莫志贤.西医院校中药药理学教学特点浅析[J].中国中医药远程教育杂志,2015,13(16):162-164.

25. 江明金,陈毅飞,彭求贤,彭菊,翁建霖,莫志贤,钩藤碱对甲基苯丙胺依赖斑马鱼大脑神经递质含量以及TH、NR2B和GluR2/3表达的影响[J].中国药理学通报,2015,11(31) :72-75

26. 黄嘉维,郝亚娟,彭求贤,麦婉盈,马嘉镁,蔡红兵,正交试验优化卜芥凝集素超声提取工艺研究,2016,04:149-152

会议论文

27. 彭求贤,刘塔斯,王晟,郭英.女贞子研究近况,2007年中华中医药学会第八届中药鉴定学术研讨会暨中国中西医结合学会中药专业委员会全国中药学术研讨会,pp电子中国官网平台学报27(S1):391-393.长沙,2007.8.1-5

28. Peng Q.X., and Yung K.K.L.Magnolol against 6-Hydroxydopamine- Induced Loss of Tyrosine Hydroxylase Involves MAP Kinase Signaling Pathways in Transgenic Zebrafish and SH-SY5Y Cell Models. 2013 Neuroscience Meeting Planner. San Diego: Society for Neuroscience,2013.11.09-15

29. Peng Q.X.,and Yung K.K.L., Reversal of nicotine addication by rhynchophylline and DNA origami through microRNAs that mediate brain-derived neurotrophic factor in zebrafish. International Conference on Eco-aquaculture and Public Health, Hong Kong, 2014. 11.28-30.

二、课题研究

1. 中国博士后特别资助项目(2015T80911):miR-506靶向抑制cav-1在尖尾芋凝集素抗乳腺癌中的作用研究,2015年9月- 2016,12,金额:15万,主持。

2. 中国博士后基金面上项目(2014M560666):Caveolin-1介导尖尾芋凝集素激活免疫抗肿瘤的作用机制,2014年9月- 2016,12,金额:8万,主持。

3. 广东省科技厅项目(2006A020226003):miR-506靶向结合cav-1在尖尾芋凝集素抗乳腺癌中的作用研究,2016年4月-今,金额:10万,主持。

4. pp电子中国官网平台博士启动基金:miR-133b-5p靶向结合GABABR2调控尼古丁依赖及钩藤碱干预作用研究,2016年12月-2018年12月,金额10万元,主持。

三、专利

1. 余惠旻,彭求贤,何翠君,杨大坚.中药复方左金方在制备治疗胃癌中的应用.中国, 200910105276.5

2. 莫志贤,翁建霖,罗超华,彭求贤,房淼,朱道琦.一种肉桂茶及其制备方法.中国,201610021148.2

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